Antiradical activity and bioprediction of o- and p-hydroxybenzoic acid hydrazide derivatives

Show simple item record

dc.contributor.author Satpaeva, Zh.B.
dc.contributor.author Nurkenov, О.А.
dc.contributor.author Schulgau, Z.Т.
dc.contributor.author Fazylov, S.D.
dc.contributor.author Burkeev, М.Zh.
dc.contributor.author Havlicek, D.
dc.date.accessioned 2020-04-16T04:30:08Z
dc.date.available 2020-04-16T04:30:08Z
dc.date.issued 2020-01-30
dc.identifier.citation Satpaeva Zh.B. Antiradical activity and bioprediction of o- and p-hydroxybenzoic acid hydrazide derivatives/Zh.B. Satpaeva[et al.]//Қарағанды универисетінің хабаршысы. Химия Сериясы.=Вестник Карагандинского университета. Серия Химия.=Bulletin of the Karaganda University. Chemistry Series.-2020.-№1(97).-P. 35-43. ru_RU
dc.identifier.issn 2663-4872
dc.identifier.uri http://rep.ksu.kz//handle/data/9616
dc.description.abstract This article provides results of evaluation of synthesized biologically active substances 1–4 antiradical activity according to their ability to interact with the 2,2- diphenyl-1-picrylhydrazyl radical (DPPH•). It was found that all synthesized compounds 1–4 have antiradical activity. Pronounced antiradical activity was shown by N-ethyl-2-(2-hydroxybenzoyl)hydrazine-carbothioamide (1) (IC50(DPPH) = 12.5 μМ) and N-ethyl-2-(4-hydroxy-benzoyl)hydrazine-carbothioamide (2) (IC50(DPPH) = 16.7 μМ) samples under the conditions of this test sys-tem. Activity of N-ethyl-2-(2-hydroxybenzoyl) hydrazinecarbothioamide (1) and N-ethyl-2-(4-hydroxyben-zoyl)hydrazinecarbothioamide (2) samples are comparable to activity of known antioxidants. Studied sub-stances 1 and 2 are promising for further advanced research of their antioxidant properties and other types of biological activity. Results of PASS computer system applicability estimation for prediction of biological ac-tivity using structural formula as a part of pre-experimental screening are provided. Expected activity of chem-ical compounds combines physiological activity of initial hydrazides of o- and p-hydroxybenzoic acids as well as components of structural molecule. According to bioprediction data analysis, all compounds can act as in-hibitors with a high degree of probability. ru_RU
dc.language.iso en ru_RU
dc.publisher KSU publ. ru_RU
dc.relation.ispartofseries Chemistry Series;№1(97)
dc.subject antioxidant ru_RU
dc.subject antiradical activity ru_RU
dc.subject free radical ru_RU
dc.subject thiosemicarbazide ru_RU
dc.subject 1,2,4-triazole ru_RU
dc.subject DPPH ru_RU
dc.subject bioprediction ru_RU
dc.subject PASS ru_RU
dc.title Antiradical activity and bioprediction of o- and p-hydroxybenzoic acid hydrazide derivatives ru_RU
dc.type Article ru_RU


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account