dc.contributor.author |
Satpaeva, Zh.B. |
|
dc.contributor.author |
Nurkenov, О.А. |
|
dc.contributor.author |
Schulgau, Z.Т. |
|
dc.contributor.author |
Fazylov, S.D. |
|
dc.contributor.author |
Burkeev, М.Zh. |
|
dc.contributor.author |
Havlicek, D. |
|
dc.date.accessioned |
2020-04-16T04:30:08Z |
|
dc.date.available |
2020-04-16T04:30:08Z |
|
dc.date.issued |
2020-01-30 |
|
dc.identifier.citation |
Satpaeva Zh.B. Antiradical activity and bioprediction of o- and p-hydroxybenzoic acid hydrazide derivatives/Zh.B. Satpaeva[et al.]//Қарағанды универисетінің хабаршысы. Химия Сериясы.=Вестник Карагандинского университета. Серия Химия.=Bulletin of the Karaganda University. Chemistry Series.-2020.-№1(97).-P. 35-43. |
ru_RU |
dc.identifier.issn |
2663-4872 |
|
dc.identifier.uri |
http://rep.ksu.kz//handle/data/9616 |
|
dc.description.abstract |
This article provides results of evaluation of synthesized biologically active substances 1–4 antiradical activity according to their ability to interact with the 2,2- diphenyl-1-picrylhydrazyl radical (DPPH•). It was found that all synthesized compounds 1–4 have antiradical activity. Pronounced antiradical activity was shown by N-ethyl-2-(2-hydroxybenzoyl)hydrazine-carbothioamide (1) (IC50(DPPH) = 12.5 μМ) and N-ethyl-2-(4-hydroxy-benzoyl)hydrazine-carbothioamide (2) (IC50(DPPH) = 16.7 μМ) samples under the conditions of this test sys-tem. Activity of N-ethyl-2-(2-hydroxybenzoyl) hydrazinecarbothioamide (1) and N-ethyl-2-(4-hydroxyben-zoyl)hydrazinecarbothioamide (2) samples are comparable to activity of known antioxidants. Studied sub-stances 1 and 2 are promising for further advanced research of their antioxidant properties and other types of biological activity. Results of PASS computer system applicability estimation for prediction of biological ac-tivity using structural formula as a part of pre-experimental screening are provided. Expected activity of chem-ical compounds combines physiological activity of initial hydrazides of o- and p-hydroxybenzoic acids as well as components of structural molecule. According to bioprediction data analysis, all compounds can act as in-hibitors with a high degree of probability. |
ru_RU |
dc.language.iso |
en |
ru_RU |
dc.publisher |
KSU publ. |
ru_RU |
dc.relation.ispartofseries |
Chemistry Series;№1(97) |
|
dc.subject |
antioxidant |
ru_RU |
dc.subject |
antiradical activity |
ru_RU |
dc.subject |
free radical |
ru_RU |
dc.subject |
thiosemicarbazide |
ru_RU |
dc.subject |
1,2,4-triazole |
ru_RU |
dc.subject |
DPPH |
ru_RU |
dc.subject |
bioprediction |
ru_RU |
dc.subject |
PASS |
ru_RU |
dc.title |
Antiradical activity and bioprediction of o- and p-hydroxybenzoic acid hydrazide derivatives |
ru_RU |
dc.type |
Article |
ru_RU |