Synthesis of hydrazone derivatives of isonicotinic acid under microwave activation conditions

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dc.contributor.author Fazylov, S.D.
dc.contributor.author Nurkenov, О.А.
dc.contributor.author Seilkhanov, Т.М.
dc.contributor.author Karipova, G.Zh.
dc.contributor.author Hecke, K. Van
dc.contributor.author Suleimen, Ye.M.
dc.contributor.author Gazaliyev, A.M.
dc.date.accessioned 2019-11-01T11:01:53Z
dc.date.available 2019-11-01T11:01:53Z
dc.date.issued 2019-09-30
dc.identifier.citation Fazylov, S.D. Synthesis of hydrazone derivatives of isonicotinic acid under microwave activation conditions / S.D. Fazylov, О.А. Nurkenov, Т.М. Seilkhanov [et al.] // Қарағанды универисетінің хабаршысы. Химия сериясы. = Вестник Карагандинского университета. Серия Химия. = Bulletin of the Karaganda University. Chemistry series. – 2019. - № 3. – P. 37-44. ru_RU
dc.identifier.issn 2518-718X
dc.identifier.issn 2663-4872
dc.identifier.uri http://rep.ksu.kz//handle/data/8605
dc.description.abstract In the article the results of studying the reaction of the interaction of isonicotinic acid hydrazide with various derivatives of aromatic aldehydes under conditions of microwave activation in an alcohol medium were described. The results of studying the dependences of the hydrazone yield on the duration of the activation time at various microwave irradiation powers in comparison with the classical method have been presented. It was found that the main factors affecting the nature of the synthesis and the yields of the target products were the power and time of microwave activation, as well as the structural features of the reactants. For all studied reactions, the optimal conditions for obtaining the target product have been shown. As a result of a comparative analysis of the results obtained for the synthesis of new isonicotinic hydrazones, it was determined that the use of microwave irradiation contributed to an increase in the yield of the product and a decrease in the reaction time by 3-4 times than according to traditional technology. The authenticity of each product is unambiguously proved by comparing the melting point, as well as by analyzing the physico-chemical characteristics with previously synthesized hydrazone derivatives of isonicotinic acid obtained by classical synthesis methods. The structure of all synthesized compounds was studied by 1H and 13C NMR spectroscopy, as well as data from two-dimensional COSY (1H-1H) spectra and HMQC (1H-13C). The developed microwave method for the synthesis of hydrazone derivatives of isonicotinic acid complies with the principles of the concept of «Green Chemistry». ru_RU
dc.language.iso en ru_RU
dc.publisher Ye.A.Buketov Karaganda State University Publishing house ru_RU
dc.relation.ispartofseries Қарағанды универисетінің хабаршысы. Химия сериясы. = Вестник Карагандинского университета. Серия Химия. = Bulletin of the Karaganda University. Chemistry series.;№ 3(95)/2019
dc.subject hydrazide of isonicotinic acid ru_RU
dc.subject hydrazone ru_RU
dc.subject aromatic aldehydes ru_RU
dc.subject microwave activation ru_RU
dc.title Synthesis of hydrazone derivatives of isonicotinic acid under microwave activation conditions ru_RU
dc.title.alternative Микротолқынды сәулелендіру жағдайында изоникотин қышқылының гидразонды туындылары синтезі ru_RU
dc.title.alternative Синтез гидразоновых производных изоникотиновой кислоты в условиях микроволновой активации ru_RU
dc.type Article ru_RU


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