Study of supramolecular inclusion complexes of pseudoephedrine, lupinine, anabasine and cytisine with β-cyclodextrin by NMR spectroscopy

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dc.contributor.author Nurkenov, O.A.
dc.contributor.author Seilkhanov, T.M.
dc.contributor.author Fazylov, S.D.
dc.contributor.author Issayeva, A.Zh.
dc.contributor.author Seilkhanov, O.T.
dc.contributor.author Vlasova, L.M.
dc.date.accessioned 2019-08-23T08:34:59Z
dc.date.available 2019-08-23T08:34:59Z
dc.date.issued 2019-06-28
dc.identifier.citation Nurkenov, O.A. Study of supramolecular inclusion complexes of pseudoephedrine, lupinine, anabasine and cytisine with β-cyclodextrin by NMR spectroscopy / O.A. Nurkenov, T.M. Seilkhanov, S.D. Fazylov [et al.] // Қарағанды универисетінің хабаршысы. Химия сериясы.=Вестник Карагандинского университета. Серия Химия.=Bulletin of the Karaganda University. Chemistry series. – 2019. – № 2. – P. 19-28. ru_RU
dc.identifier.issn 2518-718X
dc.identifier.issn 2663-4872
dc.identifier.uri http://rep.ksu.kz//handle/data/7297
dc.description.abstract The 1H, 13C and DEPT one-dimensional NMR and two-dimensional spectroscopy methods COSY (1H-1H), HMQC (1H-13C) and TOCSY (1H-1H) were used to study the alkaloids pseudoephedrine, lupinine, anabasine and cytisine and their supramolecular inclusion complexes with cyclic polysaccharide β-cyclodextrin. The proton-proton correlation patterns are presented through three bonds and the proton-carbon correlation patterns through one bond, namely COSY (1H-1H) and HMQC (1H-13C) in the molecules of the alkaloids under study. The use of the capabilities of two-dimensional spectroscopy COSY (1H-1H), HMQC (1H-13C) and TOCSY (1H-1H) to identify the studied alkaloids allowed us to correctly and unambiguously identify the structure of substrates of the supramolecular self-assembly with a cyclic polysaccharide receptor. Homonuclear and heteronuclear correlation NMR COSY (1H-1H) and HMQC (1H-13C) is also used to identify and confirm the structure and structure of the cyclic polysaccharide β-cyclodextrin. The chemical shifts of the aliphatic and hydroxyl protons of the inner and outer surfaces of the receptor were determined. A comparative analysis of the 1H and 13C NMR spectra of pseudoephedrine, lupine, anabasine and cytisine, β-cyclodextrin and their supramolecular inclusion complexes was carried out. Changes in the chemical shifts of 1H and 13C nucleus of pseudoephedrine, lupinine, anabasine, and cytisine, and β-cyclodextrin in inclusion complexes were determined. The proton integral intensities of the substrate and receptor in the 1H NMR spectra determined that the supramolecular interaction of the studied pseudoephedrine, lupinine, anabasine and cytisine with β-cyclodextrin is accompanied by the entry of hydrophobic fragments of 1 substrate molecule into the inner cavity 1 of the receptor molecule. ru_RU
dc.language.iso en ru_RU
dc.publisher Ye.A.Buketov Karaganda State University Publishing house ru_RU
dc.relation.ispartofseries Қарағанды универисетінің хабаршысы. Химия сериясы.=Вестник Карагандинского университета. Серия Химия.=Bulletin of the Karaganda University. Chemistry Series.;№ 2(94)/2019
dc.subject pseudoephedrine ru_RU
dc.subject lupinine ru_RU
dc.subject anabasine ru_RU
dc.subject cytisine ru_RU
dc.subject β-cyclodextrin ru_RU
dc.subject inclusion complexes ru_RU
dc.subject NMR spectroscopy ru_RU
dc.title Study of supramolecular inclusion complexes of pseudoephedrine, lupinine, anabasine and cytisine with β-cyclodextrin by NMR spectroscopy ru_RU
dc.title.alternative Псевдоэфедрин, лупинин, анабазин жəне цитизиннің β-циклодекстринмен супрамолекулалық қосылу кешендерін ЯМР спектроскопия əдісімен зерттеу ru_RU
dc.title.alternative Исследование супрамолекулярных комплексов включения псевдоэфедрина, лупинина, анабазина и цитизина с β-циклодекстрином методом спектроскопии ЯМР ru_RU
dc.type Article ru_RU


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