Albumin nanoparticles loaded with the antitumor drug «Hydroxycarbamide» by the incorporation method

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dc.contributor.author Tazhbayev, Ye.M.
dc.contributor.author Burkeyev, M.Zh.
dc.contributor.author Zhaparova, L.Zh.
dc.contributor.author Zhumagaliyeva, T.S.
dc.contributor.author Agdarbek, A.A.
dc.date.accessioned 2019-05-13T05:32:30Z
dc.date.available 2019-05-13T05:32:30Z
dc.date.issued 2019-03-30
dc.identifier.citation Tazhbayev, Ye.M. Albumin nanoparticles loaded with the antitumor drug «Hydroxycarbamide» by the incorporation method / Ye.M. Tazhbayev, M.Zh. Burkeyev, L.Zh. Zhaparova [et al.] // Қарағанды универисетінің хабаршысы. Химия сериясы.=Вестник Карагандинского университета. Серия Химия.=Bulletin of the Karaganda University. Chemistry series. – 2019. - №1(93). – P. 48-53. ru_RU
dc.identifier.issn 2518-718X
dc.identifier.issn 2663-4872
dc.identifier.uri http://rep.ksu.kz//handle/data/5745
dc.description.abstract In this article the possibility of loading the antitumor drug «Hydroxycarbamide» into the polymeric matrix of human serum albumin was studied. Nanoparticles of serum albumin were obtained using desolvation method. Prepared empty human serum albumin nanoparticles have average size of 108.4 nm with narrow particle size distribution, which make them promising in using for the drug delivery purposes. The binding of hydroxycarbamide with the polymer was performed by incorporation of the drug into the medium during the process of crosslinking of albumin macromolecules. Incorporation of the drug into human serum albumin led to the formation of nanoparticles loaded with hydroxycarbamide with satisfactory physico-chemical characteristics (average particle diameters were in the range of 250–350 nm and the value of polydispersity index was 0.2–0.3) with the high value of binding degree (up to 68 %). It was shown that increasing the concentration of the drug in the initial solution led to the increase of binding degree of hydroxycarbamide with human serum albumin nanoparticles. The kinetics of release process of the drug from albumin nanoparticles in the conditions modeling biological medium was studied. As a result of the study of the drug release rate it has been concluded that prolonged release of hydroxycarbamide can be achieved when nanosomal form of the drug is used. ru_RU
dc.language.iso en ru_RU
dc.publisher Ye.A.Buketov Karaganda State University Publishing house ru_RU
dc.relation.ispartofseries Қарағанды универисетінің хабаршысы. Химия сериясы.=Вестник Карагандинского университета. Серия Химия.=Bulletin of the Karaganda University. Chemistry series.;№ 1(93)/2019
dc.subject nanoparticles ru_RU
dc.subject human serum albumin ru_RU
dc.subject desolvation ru_RU
dc.subject antitumor drug ru_RU
dc.subject Hydroxycarbamide ru_RU
dc.subject incorporation ru_RU
dc.subject loading ru_RU
dc.subject drug delivery ru_RU
dc.subject polymers ru_RU
dc.title Albumin nanoparticles loaded with the antitumor drug «Hydroxycarbamide» by the incorporation method ru_RU
dc.title.alternative Қатерлі ісікке қарсы «Гидроксикарбамид» препаратымен енгізу əдісімен иммобилденген альбуминді нанобөлшектер ru_RU
dc.title.alternative Наночастицы альбумина, иммобилизованные противоопухолевым препаратом «Гидроксикарбамид» методом включения ru_RU
dc.type Article ru_RU


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