Concentration of complex Zn+2–chelator around blood vessels in pancreatic islets result alteration and destruction of capillaries

Meyramov, G.G.; Kohnert, K.-D.; Williams, A.A.; Kikimbaeva, A.A.; Turgunova, L.G.; Tyrzhanova, S.S.; Alina, A.R.; Shaybek, A.Zh.; Abdullina, G.A.; Zhuzbaeva, G.O.; Kovalenko, O.L.; Meyramova, A.G.

dc.contributor.author	Meyramov, G.G.
dc.contributor.author	Kohnert, K.-D.
dc.contributor.author	Williams, A.A.
dc.contributor.author	Kikimbaeva, A.A.
dc.contributor.author	Turgunova, L.G.
dc.contributor.author	Tyrzhanova, S.S.
dc.contributor.author	Alina, A.R.
dc.contributor.author	Shaybek, A.Zh.
dc.contributor.author	Abdullina, G.A.
dc.contributor.author	Zhuzbaeva, G.O.
dc.contributor.author	Kovalenko, O.L.
dc.contributor.author	Meyramova, A.G.
dc.date.accessioned	2019-04-08T06:35:44Z
dc.date.available	2019-04-08T06:35:44Z
dc.date.issued	2014-12-30
dc.identifier.citation	Meyramov, G.G., Kohnert, K.-D., Williams, A.A., Kikimbaeva, A.A., Turgunova, L.G., Tyrzhanova, S.S., Alina, A.R., Shaybek, A.Zh., Abdullina, G.A., Zhuzbaeva, G.O., Kovalenko, O.L., Meyramova, A.G. Concentration of complex Zn+2–chelator around blood vessels in pancreatic islets result alteration and destruction of capillaries/G.G.Meyramov [et al]//Қарағанды университетінің хабаршысы. Биология. Медицина. География сериясы = Вестник Карагандинского университета. Серия Биология. Медицина. География. - 2014. №4. С.96-100	ru_RU
dc.identifier.issn	0142-0843
dc.identifier.uri	http://rep.ksu.kz:80//handle/data/4901
dc.description.abstract	Authors showed that concentration around capillaries wall of complex Zn+2-chelator formed in result of interaction in cytoplasm of B-cells of Zn+2-ions with diabetogenic zincbinding chelators is one of causes of developed vascular changes in capillaries of pancreatic islets. These changes as alteration of basal membrane of capillaries, edema of endothelium, partial destruction of capillaries wall and hyperemia can to aggravate developing of degenerative changes in pancreatic islets induced by Zn+2-chelator that result aggravation developing of diabetes. Meanwhile main cause of developing of diabetes induced by zincbinding chelators is its ability to form toxic complexes with Zn+2-ions in B-cells that result necrosis and destruction of B-cells within short time.	ru_RU
dc.language.iso	other	ru_RU
dc.publisher	Pub KSU	ru_RU
dc.relation.ispartofseries	Қарағанды университетінің хабаршысы. Биология. Медицина. География сериясы = Вестник Карагандинского университета. Серия Биология. Медицина. География.;№4(76)/2014
dc.subject	pancreatic islets	ru_RU
dc.subject	insulin, Zn+2-ions	ru_RU
dc.subject	B-cells	ru_RU
dc.subject	destruction	ru_RU
dc.subject	blood vessel	ru_RU
dc.subject	chelat complexes	ru_RU
dc.subject	vascular changes	ru_RU
dc.subject	diabetogenic derivatives of 8-oxyquinolin	ru_RU
dc.title	Concentration of complex Zn+2–chelator around blood vessels in pancreatic islets result alteration and destruction of capillaries	ru_RU
dc.title.alternative	Қылтамырлар қабырғасының бұзылуымен қоса жүретін панкреатиттік аралшықтардағы қылтамырлар маңайындағы «Zn+2–хелатор» кешенінің қалыптасуы	ru_RU
dc.title.alternative	Формирование комплекса «Zn+2–хелатор» вокруг капилляров в панкреатических островках, сопровождающееся деструкцией их стенки	ru_RU
dc.type	Article	ru_RU