Abstract:
Authors showed that concentration around capillaries wall of complex Zn+2-chelator formed in result of interaction
in cytoplasm of B-cells of Zn+2-ions with diabetogenic zincbinding chelators is one of causes of developed
vascular changes in capillaries of pancreatic islets. These changes as alteration of basal membrane of
capillaries, edema of endothelium, partial destruction of capillaries wall and hyperemia can to aggravate developing
of degenerative changes in pancreatic islets induced by Zn+2-chelator that result aggravation developing
of diabetes. Meanwhile main cause of developing of diabetes induced by zincbinding chelators is its
ability to form toxic complexes with Zn+2-ions in B-cells that result necrosis and destruction of B-cells within
short time.