Abstract:
There was studied protonation of aminothiazoles of mineral acids of different strength in order to research the
basicity of nitrogen atoms of free amino group and nitrogen of thiazole ring. The results obtained showed
high ambidentity of 2-amino-4-phenylthiazole and 2-amino-4-oxothiazole associated with a high degree of
delocalization of both the lone pair of electrons of the amino group and the thiazole ring nitrogen atom which
creates opportunities for chemical modification of the aminoheterocycles with the free amino group and the
ring nitrogen atom. Сomplexing ability of 2-amino-4-oxothiazole with cobalt (II) chloride caused by high degree
of basicity of cyclic nitrogen atom was also studied.
