Abstract:
In this work, methods for directed synthesis of practically significant derivatives of guaianolide estafiatine
were considered. It is shown that α-epoxy cycle, which is present in the molecule of estafiatine determines the
stereo — and regioselectivity of nucleophilic addition and obtaining new biologically active derivatives. Discussed
in this paper sesquiterpene lactone estafiatine and its derivatives were studied in terms of obtaining
new biologically active compounds and the influence of structural features of the molecules of this series on
their biological activity. During of performed bio-experiments, growth regulatory activity of series of
estafiatine derivatives was found.
