Preparation and characterization of empty nanoparticles of poly-D,L-lactic acid and serum albumin

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dc.contributor.author Tazhbayev, Ye.M.
dc.contributor.author Burkeyev, M.Zh.
dc.contributor.author Zhaparova, L.Zh.
dc.contributor.author Zhumagalieva, T.S.
dc.contributor.author Arystanova, Zh.T.
dc.contributor.author Mukhanova, D.A.
dc.date.accessioned 2019-02-26T07:54:24Z
dc.date.available 2019-02-26T07:54:24Z
dc.date.issued 2018
dc.identifier.citation Preparation and characterization of empty nanoparticles of poly-D,L-lactic acid and serum albumin /Ye.M. Tazhbayev, M.Zh. Burkeyev, L.Zh. Zhaparova, T.S. Zhumagalieva, Zh.T. Arystanova, D.A. Mukhanova //Қарағанды университетінің хабаршысы. Химия сериясы.=Вестник Карагандинского университета. Серия Химия=Bulletin of the Karaganda University. Chemistry series.-2018.-№2.-Р.40-44 ru_RU
dc.identifier.issn 2518-718Х
dc.identifier.uri http://rep.ksu.kz/handle/data/3793
dc.description.abstract The methods of preparation of polymeric nanoparticles and nanocapsules on the basis of such polymers as human serum albumin and poly-D,L-lactic acid are shown in this article. Human serum albumin and poly- D,L-lactic acid are well-known polymers used in medicine for different purposes including delivery of some potent drugs in the forms of nanoparticles. Empty nanoparticles of human serum albumin and poly-D,L-lactic acid have been successfully synthesized using desolvation and nanoprecipitation methods correspondingly. Optimal conditions of synthesizing the nanoparticles of human serum albumin and poly-D,L-lactic acid have been worked out. Obtained nanoparticles of the polymers have satisfactory physicochemical characteristics: the particle sizes were in the interval of 100–300 nm with narrow particle size distribution which points on the formation of nanoparticles of similar size. The surface charge of the particles was defined as it is the parameter that determines the stability of the system. The meanings of zetapotential were around –30 mV for both systems which justifies the stability of particles within the time. So the results of this study have shown that synthesized nanoparticles of human serum albumin and poly-D,L-lactic acid have good characteristics and hence they can further be used for loading them with different drugs. ru_RU
dc.language.iso en ru_RU
dc.publisher Ye.A.Buketov Karaganda State University Publishing house ru_RU
dc.relation.ispartofseries Bulletin of the Karaganda University. Chemistry series;№2(90)/2018
dc.subject polymers ru_RU
dc.subject polylactic acid ru_RU
dc.subject human serum albumin ru_RU
dc.subject nanoparticles ru_RU
dc.subject drug delivery ru_RU
dc.subject nanocapsules ru_RU
dc.subject nanoprecipitation ru_RU
dc.subject desolvation ru_RU
dc.title Preparation and characterization of empty nanoparticles of poly-D,L-lactic acid and serum albumin ru_RU
dc.title.alternative Поли-D,L-сүт қышқылы мен сарысу альбуминнің бос нанобөлшектерін синтездеу жəне сипаттау ru_RU
dc.title.alternative Получение и характеристика пустых наночастиц поли-D,L-молочной кислоты и сывороточного альбумина ru_RU
dc.type Article ru_RU


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