Abstract:
The methods of preparation of polymeric nanoparticles and nanocapsules on the basis of such polymers as
human serum albumin and poly-D,L-lactic acid are shown in this article. Human serum albumin and poly-
D,L-lactic acid are well-known polymers used in medicine for different purposes including delivery of some
potent drugs in the forms of nanoparticles. Empty nanoparticles of human serum albumin and poly-D,L-lactic
acid have been successfully synthesized using desolvation and nanoprecipitation methods correspondingly.
Optimal conditions of synthesizing the nanoparticles of human serum albumin and poly-D,L-lactic acid have
been worked out. Obtained nanoparticles of the polymers have satisfactory physicochemical characteristics:
the particle sizes were in the interval of 100–300 nm with narrow particle size distribution which points on
the formation of nanoparticles of similar size. The surface charge of the particles was defined as it is the parameter
that determines the stability of the system. The meanings of zetapotential were around –30 mV for
both systems which justifies the stability of particles within the time. So the results of this study have shown
that synthesized nanoparticles of human serum albumin and poly-D,L-lactic acid have good characteristics
and hence they can further be used for loading them with different drugs.
