Nanoparticles on the basis of polylactic acid and polylactic-co-glycolic acids loaded with drugs

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dc.contributor.author Tazhbayev, Ye.M.
dc.contributor.author Burkeyev, M.Zh.
dc.contributor.author Zhaparova, L.Zh.
dc.contributor.author Zhumagalieva, T.S.
dc.contributor.author Arystanova, Zh.T.
dc.date.accessioned 2019-02-26T07:39:12Z
dc.date.available 2019-02-26T07:39:12Z
dc.date.issued 2018
dc.identifier.citation Nanoparticles on the basis of polylactic acid and polylactic-co-glycolic acids loaded with drugs /Ye.M. Tazhbayev, M.Zh. Burkeyev, L.Zh. Zhaparova, T.S. Zhumagalieva, Zh.T. Arystanova //Қарағанды университетінің хабаршысы. Химия сериясы.=Вестник Карагандинского университета. Серия Химия=Bulletin of the Karaganda University. Chemistry series.-2018.-№2.-Р.31-39 ru_RU
dc.identifier.issn 2518-718Х
dc.identifier.uri http://rep.ksu.kz/handle/data/3792
dc.description.abstract In this article a brief review on the research works devoted to the synthesis and investigation of polymeric nanoparticles and nanocapsules on the basis of polylactic acid and its copolymer with polyglycolic acid is given. Nanoparticles based on biocompatible and biodergadable polylactic acid and polylactic-co-glycolic acids gained special interest in pharmaceutical field as the carriers of different drug preparations. General methods of synthesizing nanosomal formulations of polylactic acid and polylactic-co-glycolic acids were described in this work. Among the perspective methods of obtaining the polymeric nanoparticles and nanocapsules of polylactides and its copolymer with glycolic acid loaded with drugs the nanoprecipitation and emulsion methods were found to be the most suitable for the systems used. Another method of synthesizing the nanosized systems of polylactic-co-glycolic acid is a double emulsion method which makes possible to obtain nanocapsules with optimal characteristics. The possibilities of immobilization of nanoparticulate systems based on these polymers with antitumor and antituberculosis drugs were considered. Some examples of polylactic acid and polylactic-co-glycolic acids’ nanoparticles and nanocapsules loaded with drugs which have applications in medicine for the treatment of tumor and tuberculosis diseases were shown. ru_RU
dc.language.iso en ru_RU
dc.publisher Ye.A.Buketov Karaganda State University Publishing house ru_RU
dc.relation.ispartofseries Bulletin of the Karaganda University. Chemistry series;№2(90)/2018
dc.subject polylactic acid ru_RU
dc.subject polylactic-co-glycolic acid ru_RU
dc.subject nanoparticles ru_RU
dc.subject antitumor drugs ru_RU
dc.subject antituberculosis drug ru_RU
dc.subject drug delivery ru_RU
dc.subject polymers ru_RU
dc.subject nanocapsules ru_RU
dc.title Nanoparticles on the basis of polylactic acid and polylactic-co-glycolic acids loaded with drugs ru_RU
dc.title.alternative Дəрілік заттармен иммобилизацияланған полисүт қышқылы мен полилактидгликолид негізіндегі нанобөлшектер ru_RU
dc.title.alternative Наночастицы на основе полимолочной кислоты и полилактидгликолида, иммобилизованные лекарственными препаратами ru_RU
dc.type Article ru_RU


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