Abstract:
In this article a brief review on the research works devoted to the synthesis and investigation of polymeric
nanoparticles and nanocapsules on the basis of polylactic acid and its copolymer with polyglycolic acid is
given. Nanoparticles based on biocompatible and biodergadable polylactic acid and polylactic-co-glycolic acids
gained special interest in pharmaceutical field as the carriers of different drug preparations. General methods
of synthesizing nanosomal formulations of polylactic acid and polylactic-co-glycolic acids were described
in this work. Among the perspective methods of obtaining the polymeric nanoparticles and
nanocapsules of polylactides and its copolymer with glycolic acid loaded with drugs the nanoprecipitation
and emulsion methods were found to be the most suitable for the systems used. Another method of synthesizing
the nanosized systems of polylactic-co-glycolic acid is a double emulsion method which makes possible
to obtain nanocapsules with optimal characteristics. The possibilities of immobilization of nanoparticulate
systems based on these polymers with antitumor and antituberculosis drugs were considered. Some examples
of polylactic acid and polylactic-co-glycolic acids’ nanoparticles and nanocapsules loaded with drugs which
have applications in medicine for the treatment of tumor and tuberculosis diseases were shown.
