Abstract:
In this paper, the results of a study of the biological activity of amino derivatives of sesquiterpene lactone
santonin are shown. The study of the antioxidant activity of santonin and their amino derivatives was carried
out using the method of initiated biochemiluminescence. And also the above-ground part of the plant Artemisia
gracil. Krasch. — wormwood finely-chained by the chloroform extraction method, the sum of extractive
substances is obtained. As a result of column chromatography of the sum of extractive substances,
sesquiterpenoid santonin was isolated. Synthesis of natural sesquiteroids with an amino group allows the
preparation of new compounds with a wide spectrum of biological activity, as well as the formation of compounds
that have a higher solubility in water than the original lipophilic sesquiterpenoids. Considering this,
the reaction of santonine with primary amines with monoethanolamine and methylamine was studied. The
structures of santonine and amino derivatives were identified using modern physicochemical methods and IR
and PMR spectra. 13C NMR spectra were recorded on Bruker AC 200 spectrometers [operating frequencies
200]
