Abstract:
Data on the synthesis and study of the effect of 2-morpholino-N-(propane-2-ylidene) acetohydrazide and
2-(2-morpholinoacetyl)-N-phenylhydrazinocarbothioamide hydrochloride on the electroreduction of oxygen
(EV O2) in various concentrations were presented. The structures of synthesized compounds were studied by
IR and 1H NMR spectroscopy methods. Cathode voltammetry on a mercury-film electrode was used as a
method for estimating the antioxidant activity of samples. In this approach, the determination of antioxidant
activity reflected the number of active forms of oxygen neutralized by the antioxidant in a certain time. The
change in the current of the O2 OV in its absolute value indicated that the samples under study reacted with
oxygen and its active radicals in the test solution. The degree of change in the current of the O2 OV was an
indicator of the activity of the sample under study. A similar voltammogram was obtained for the substance
under study. A decrease in the cathodic current of E2 O2 is observed, which indicates that they exhibit antioxidant
activity with respect to this process. In addition, there was a shift in the potential of the cathode current
of the O2O2 to the positive potential region. All of the above implies the existence of an EU mechanism (electrochemical
— chemical stage), which includes the subsequent chemical reaction of the interaction of antioxidants
with active oxygen radicals. It is shown that the aqueous solution of the studied morpholine derivatives
exhibits antioxidant activity.
