Abstract:
It is known that Zinc which is contains in pancreatic β-cells of take participation in formation of deposited
storage form of insulin in cells. It is known now a 18 Diabetogenic zinc binding β-cytotoxic chemicals (DZC)
which in β-cells formed toxic chelat complexes that result destruction and death of β-cells within 15–30 min.
and developing of diabetes. Among 18 DZC 17 of them are belong to derivatives of 8-oxyquinolin which are
a components of more than 10 pharmaceutical drugs. It is known also that administration of amino acid a Reduced
form of Glutathione completely protect pancreatic B-cells of destruction and prevent developing of diabetes
caused by DZC. It is supposed that this property of Glutathione is determined by its ability to block of
zinc in B-cells and to prevent interaction of it with DZC. Authors using of sensitive and high specific
histochemical methods established that only Reduced form of Glutathione contains of SH-radical in structure
of molecule blocked zinc ions in β-cells and protect of its from destruction caused by DZC contrary to Oxidized
form of Glutathione not contains of SH-radical, not blocking of zinc ions in β-cells and not protect formation
of zinc-DZC complexes in β-cells accompanied by death of cells. Authors suppose that in process of
formation of toxic complexes as zinc-DZC atom of zinc is fixed between atom of S from SH-radicals of two
molecules of Reduced form of Glutathione or between atom of O of a carboxyl group and atom of S of SHradical
of molecule of Glutathione as in result of interaction of zinc with diabetognic derivatives of
8-oxyquinolin.
