Abstract:
This article is devoted to preparation of polyelectrolytic microcapsules of two antitubercular drugs (ATDs) as
the new drug delivery system (DDS). Co-encapsulation of oral antitubercular drugs pyrazinamide and
moxifloxcin by polyelectrolytic multilayers is carried out for the first time. At first by ionotropic gelation
method co-encapsulation of drugs to a polymeric matrix carried out. As a matrix biopolymers gellan and sodium
alginate were used. The co-encapsulation efficiency was determined using UV-spectroscopy method as
it is specified in the State pharmacopeia of the Republic of Kazakhstan. Then by the method of fiber adsorption
(LbL-technique — Layer by layer deposition) on microcapsules sequentially coated a cationic polyelectrolyte
chitosan and an anionic polyelectrolyte eudragit S100. The charge of each layer was determined by
zeta-potential measurement. Microcapsules about 3, 5 and 10 bilayers of polyelectrolytes are prepared. The
structure of microcapsules was studied by method of the scanning submicroscopy. In vitro drug release studies
carried out at values рН, modeling various sites of digestive tract. As a result of a research it is shown that
microcapsules possess the prolonged action. With increase in number of bilayers extent of prolongation of
drugs increases. It is enough 5 bilayers of polyelectrolytes to achieve the 24th hour prolongation of drugs.
