Synthesis, structure and computer bioprognosis new hydrazons based on hydrosides o- and p-hydroxybenzoic acids

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dc.contributor.author Nurkenov, О.А.
dc.contributor.author Satpaeva, Zh.B.
dc.contributor.author Fazylov, S.D.
dc.contributor.author Turdybekov, К.М.
dc.contributor.author Seilkhanov, Т.М.
dc.contributor.author Suleimen, Ye.М.
dc.contributor.author Iskakova, Zh.B.
dc.date.accessioned 2018-04-25T05:02:36Z
dc.date.available 2018-04-25T05:02:36Z
dc.date.issued 2017-09-29
dc.identifier.citation Synthesis, structure and computer bioprognosis new hydrazons based on hydrosides o- and p-hydroxybenzoic acids/О.А. Nurkenov [et al]//Қарағанды универисетінің хабаршысы. ХИМИЯ Сериясы.=Вестник Карагандинского университета. Серия ХИМИЯ.=Bulletin of the Karaganda University. CHEMISTRY Series.-2017. №3.Р.18-30. ru_RU
dc.identifier.uri http://rep.ksu.kz/handle/data/2714
dc.description.abstract Interaction of hydrazides of o- and p-hydroxybenzoic acids with substituted aromatic aldehydes yielded the corresponding hydrazone derivatives. Using the computer program PASS, a bioproject of N-arylidene hydrazones was carried out and it was shown that their expected activity combines both the physiological activity of the initial hydrazides of o- and p-hydroxybenzoic acids and the constituent components of the structural molecule. The structures of the synthesized compounds were studied by 1H NMR and 13C NMR spectroscopy, as well as with the data of the two-dimensional spectra COSY (1H-1H) and HMQC (1H-13C). The values of chemical shifts, multiplicity and integrated intensity of the 1H and 13C signals in one-dimensional NMR spectra are determined. Homogeneous and heteronuclear interactions are established using spectra in the formats COSY (1H-1H) and HMQC (1H-13C), confirming the structure of the compounds under study. X-ray diffraction study of N-(5-bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide, whose molecule is bound by a hydrogen bond to an ethanol solvate molecule. ru_RU
dc.language.iso en ru_RU
dc.publisher KSU Publ. ru_RU
dc.relation.ispartofseries Қарағанды универисетінің хабаршысы. ХИМИЯ Сериясы.=Вестник Карагандинского университета. Серия ХИМИЯ.=Bulletin of the Karaganda University. CHEMISTRY Series.;№ 3(87)/2017
dc.subject o- and p-hydroxybenzoic acid hydrazide ru_RU
dc.subject hydrazone ru_RU
dc.subject aromatic aldehydes ru_RU
dc.subject NMR spectroscopy ru_RU
dc.title Synthesis, structure and computer bioprognosis new hydrazons based on hydrosides o- and p-hydroxybenzoic acids ru_RU
dc.title.alternative о- жəне п-гидроксибензой қышқылдары негізіндегі жаңа гидразондардың синтезі, құрылымы мен компьютерлік биоболжам ru_RU
dc.title.alternative Синтез, строение и компьютерный биопрогноз новых гидразонов на основе гидразидов о- и п-гидроксибензойных кислот ru_RU
dc.type Article ru_RU


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