Synthesis and structure of condensed biheterocycles on the basis of 3-amino-1,2,4-triazole

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dc.contributor.author Nurkenov, О.А.
dc.contributor.author Fazylov, S.D.
dc.contributor.author Seilkhanov, Т.М.
dc.contributor.author Arinova, А.Е.
dc.contributor.author Issayeva, А.Zh.
dc.contributor.author Satpaeva, Zh.B.
dc.contributor.author Karipova, G.Zh.
dc.date.accessioned 2018-04-25T04:31:40Z
dc.date.available 2018-04-25T04:31:40Z
dc.date.issued 2017-09-29
dc.identifier.citation Synthesis and structure of condensed biheterocycles on the basis of 3-amino-1,2,4-triazole/О.А. Nurkenov [et al]//Қарағанды универисетінің хабаршысы. ХИМИЯ Сериясы.=Вестник Карагандинского университета. Серия ХИМИЯ.=Bulletin of the Karaganda University. CHEMISTRY Series.-2017. №3.Р.9-17. ru_RU
dc.identifier.uri http://rep.ksu.kz/handle/data/2709
dc.description.abstract The article is devoted to the development of preparatively convenient methods for the synthesis of new derivatives of 3-amino-1,2,4-triazole with the aim of constructing new condensed systems of industrially important substances. The synthesis of triazolopyrimidines, prepared by three-component condensation of 1,3-dicarbonyl compounds (anilide of acetoacetic acid and acetoacetic ether) with substituted aromatic aldehydes and 3-amino-1,2,4-triazole. It is shown that by melting at 120–140 ºC, in the absence of a solvent in equimolecular amounts of acetylacetyl anilide and acetoacetic ether with a mixture of 3-amino-1,2,4-triazole and substituted aromatic aldehydes (3-ethoxy-4-hydroxybenzaldehyde, salicylic aldehyde), leads to the 7-aryl-5- methyl-N-phenyl-4,7-dihydro-[1,2,4-triazolo][1,5-a]pyrimidine-6-carboxamides and ethyl 7-aryl-5-methyl- 4,7-dihydro-[1,2,4-triazolo][1,5-a]pyrimidin-6-carboxylate-titrate respectively. The structures of the synthesized compounds were studied by 1H and 13C NMR spectroscopy, as well as with the data of the twodimensional spectra of COSY (1H-1H) and HMQC (1H-13C). The values of chemical shifts, multiplicity and integrated intensity of the 1H and 13C signals in one-dimensional NMR spectra are determined. Homo- and heteronuclear interactions were established using spectra in the formats COSY (1H-1H) and HMQC (1H-13C), confirming the structure of the compounds under study. ru_RU
dc.language.iso en ru_RU
dc.publisher KSU Publ. ru_RU
dc.relation.ispartofseries Қарағанды универисетінің хабаршысы. ХИМИЯ Сериясы.=Вестник Карагандинского университета. Серия ХИМИЯ.=Bulletin of the Karaganda University. CHEMISTRY Series.;№ 3(87)/2017
dc.subject 3-amino-1,2,4-triazole ru_RU
dc.subject 7-aryl-5-methyl-N-phenyl-4,7-dihydro-[1,2,4-triazolo][1,5-a]pyrimidine- 6-carboxamides ru_RU
dc.subject aromatic aldehydes ru_RU
dc.subject 1H- and 13C NMR-spectra ru_RU
dc.title Synthesis and structure of condensed biheterocycles on the basis of 3-amino-1,2,4-triazole ru_RU
dc.title.alternative 3-Амино-1,2,4-триазол негізінде конденсирленген бигетероциклдердің синтезі мен құрылымы ru_RU
dc.title.alternative Синтез и строение конденсированных бигетероциклов на основе 3-амино-1,2,4-триазола ru_RU
dc.type Article ru_RU


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