Analysis of the interaction of ACE2, TMPRSS2 genes and their polymorphisms with the SARS-CoV-2 virus

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dc.contributor.author Bisseneva, A.K.
dc.contributor.author Pogossyan, G.P.
dc.contributor.author Li, K.G.
dc.contributor.author Danilenko, M.P.
dc.date.accessioned 2022-06-03T09:18:47Z
dc.date.available 2022-06-03T09:18:47Z
dc.date.issued 2022
dc.identifier.citation Analysis of the interaction of ACE2, TMPRSS2 genes and their polymorphisms with the SARS-CoV-2 virus/Bisseneva A.K. [et al.] // Қарағанды университетінің хабаршысы. Биология. Медицина. География сериясы = Вестник Карагандинского университета. Серия Биология. Медицина. География = Bulletin of the Karaganda University. Biology. Medicine. Geography Series. - 2022. - №1. - pp.42-48. ru_RU
dc.identifier.issn 2663-5003
dc.identifier.uri https://rep.ksu.kz//handle/data/13074
dc.description.abstract Host genes act as a factor related to susceptibility and resistance to viral infections. The article provides a description of modern scientific studies devoted to the study of the role of the ACE2, TMPRSS2 genes, and their single-nucleotide polymorphisms in infection with the SARS-CoV-2 virus. SNPs of the ACE2 gene, TMPRSS2 can affect the penetration of SARS-CoV-2 into the cell. In addition, the study of these polymorphisms will determine the predisposition of an individual to the disease COVID–19, or the nature of its course. Based on the literature sources, the role of angiotensin-converting enzyme 2 and transmembrane proteases in the participation of the SARS-CoV-2 virus penetration process with the body cells is noted. Other functions that ACE2 and TMPRSS2 receptors perform in the human body are also described. The characteristics of two genes and their fairly well-known polymorphisms are given. The tissues and organs in which genes are expressed are marked. Information on the frequency of alleles of genetic variants of genes in different populations is shown. In addition to describing the relationship of gene polymorphisms with the disease caused by SARSCoV- 2, information is provided on the association of these genetic variations with diseases of the blood vascular system and oncological diseases. ru_RU
dc.language.iso en ru_RU
dc.publisher KU Publ. ru_RU
dc.relation.ispartofseries Қарағанды университетінің хабаршысы. Биология. Медицина. География сериясы = Вестник Карагандинского университета. Серия Биология. Медицина. География = Bulletin of the Karaganda University. Biology. Medicine. Geography Series. ;№1(105)/2022;
dc.subject ACE2 ru_RU
dc.subject TMPRSS2 ru_RU
dc.subject genes ru_RU
dc.subject SARS-CoV-2 ru_RU
dc.subject COVID-19 ru_RU
dc.subject single nucleotide polymorphisms ru_RU
dc.subject receptors ru_RU
dc.title Analysis of the interaction of ACE2, TMPRSS2 genes and their polymorphisms with the SARS-CoV-2 virus ru_RU
dc.type Article ru_RU


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