Abstract:
This article considers some aspects of synthesis and characterization of polylactide-co-glycolide nanoparticles
immobilized with the antituberculous drug isoniazid. The influence of some synthesis parameters of
nanoparticles (the ratio of drug substance: polymer and surfactant concentration) on properties of the obtained
nanosomal drug form of isoniazid has been studied. Optimal conditions for obtaining the nanoparticles with
the best physicochemical parameters such as: particle size, polydispersity, conversion, etc. have been found.
These nanoparticles can be used as drug carriers.The results revealed that a polymer: drug ratio of 1:1 and the
use of 3 % Twin 80 are necessary to obtain stable emulsions of nanoparticles of polylactide-co-glycolide with
satisfactory characteristics. Average size of the obtained particles was 196.4 nm, and the polydispersity value
was 0.323. The aggregation stability of nanoparticles during 4 hours at temperatures of 4ºC and 20ºC has
been evaluated. The morphology of the obtained nanoparticles has been studied. Analysis of nanoparticles
was characterized by various instrumental methods including gas chromatography and thermogravimetry
techniques. The resulting nanoparticles of polylactide-co-glycolide immobilized with isoniazid are stable in
time and can prolong the action of the drug. In vitro release of isoniazid from polylactide-co-glycolide
nanoparticles has been studied.
