Synthesis and structure of thiourea derivatives of functionally substituted pyridines

Show simple item record

dc.contributor.author Nurkenov, O.A.
dc.contributor.author Fazylov, S.D.
dc.contributor.author Seilkhanov, T.M.
dc.contributor.author Nurmaganbetov, Zh.
dc.contributor.author Gazaliev, A.M.
dc.contributor.author Karipova, G.Zh.
dc.date.accessioned 2021-09-22T06:23:12Z
dc.date.available 2021-09-22T06:23:12Z
dc.date.issued 2021-03-30
dc.identifier.citation Nurkenov O.A. Synthesis and structure of thiourea derivatives of functionally substituted pyridines/O.A. Nurkenov [et. al]//Қарағанды университетінің хабаршысы. Химия сериясы.= Вестник Карагандинского университета. Серия Химия. = Bulletin of the Karaganda University. Chemistry Series. -2021. №1. Р.4-11. ru_RU
dc.identifier.uri http://rep.ksu.kz/xmlui/handle/data/11045
dc.description.abstract The article presents data on the synthesis and study of the structure of thiourea derivatives of functionally substituted pyridines. New thiourea derivatives containing a pharmacologically active pyridine moiety in their structure were obtained. As the starting synton, 2-amino-5-bromopyridine, 2-amino-3-hydroxypyridine and 2-aminomethylpyridine were selected. It was shown that the interaction of 2-amino-5-bromopyridine, 2-amino-3-hydroxypyridine and 2-aminomethylpyridine with ethyl and phenylisothiocyanates in ethanol leads to the formation of the corresponding pyridine-containing thioureas. The synthesis of the initial isothiocyanates was carriedout in situ from the corresponding acidic chlorides (benzoyl chloride and p-brombenzoyl chloride) by heating them with potassium thiocyanate in acetone. The structure of the synthesized compounds was studied by 1H and 13C NMR spectroscopy, as well as by the data of two-dimensional spectra of COSY (1H-1H) and HMQC (1H-13C). The values of chemical shifts, multiplicity, and integrated intensity of 1H and 13C signals in one-dimensional NMR spectra were determined. Using spectra in the formats COSY (1Н-1Н) and HMQC (1Н-13С), homo- and heteronuclear interactions were established, confirming the structure of the studied compounds. ru_RU
dc.language.iso en ru_RU
dc.publisher KU Publ. ru_RU
dc.relation.ispartofseries Қарағанды университетінің хабаршысы. Химия сериясы.= Вестник Карагандинского университета. Серия Химия. = Bulletin of the Karaganda University. Chemistry Series.;№1(101)/2021
dc.subject ethylisothiocyanates ru_RU
dc.subject phenylisothiocyanates ru_RU
dc.subject 2-amino-5-bromopyridine ru_RU
dc.subject 2-amino-3-hydroxypyridine ru_RU
dc.subject 2-aminomethylpyridine ru_RU
dc.subject thioureas ru_RU
dc.subject 2-aminopyridine ru_RU
dc.subject 1H and 13C NMR spectra ru_RU
dc.title Synthesis and structure of thiourea derivatives of functionally substituted pyridines ru_RU
dc.title.alternative Функционалдық-орынбасылған пиридиндердің тиомочевинді туындыларының синтезі және құрылысы ru_RU
dc.title.alternative Синтез и строение тиомочевинных производных функционально-замещенных пиридинов ru_RU
dc.type Article ru_RU


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account