Abstract:
The article presents data on the synthesis and study of the structure of thiourea derivatives of functionally
substituted pyridines. New thiourea derivatives containing a pharmacologically active pyridine moiety in their
structure were obtained. As the starting synton, 2-amino-5-bromopyridine, 2-amino-3-hydroxypyridine and
2-aminomethylpyridine were selected. It was shown that the interaction of 2-amino-5-bromopyridine,
2-amino-3-hydroxypyridine and 2-aminomethylpyridine with ethyl and phenylisothiocyanates in ethanol
leads to the formation of the corresponding pyridine-containing thioureas. The synthesis of the initial
isothiocyanates was carriedout in situ from the corresponding acidic chlorides (benzoyl chloride and
p-brombenzoyl chloride) by heating them with potassium thiocyanate in acetone. The structure of the synthesized
compounds was studied by 1H and 13C NMR spectroscopy, as well as by the data of two-dimensional
spectra of COSY (1H-1H) and HMQC (1H-13C). The values of chemical shifts, multiplicity, and integrated intensity
of 1H and 13C signals in one-dimensional NMR spectra were determined. Using spectra in the formats
COSY (1Н-1Н) and HMQC (1Н-13С), homo- and heteronuclear interactions were established, confirming the
structure of the studied compounds.
