Abstract:
Authors showed that administration of diabetic zinc binders (DZC) to animals is accompanied not only by
destruction and death of B cells, but also by the development of morphological changes in the capillaries of
pancreatic islets at the site of contact with B cells (destruction of the capillary endothelium sites, change in the
shape of the capillary lumen, erythrocytes adhesion, perivascular edema, hyperemia). Vascular changes are
usually late complications of diabetes. To answer the question: are the described changes in islet capillaries a
late complication of diabetes (1) or is it the result of the direct damaging effect of DZC (2), low doses of DZC
that do not cause diabetes in animals are used, forming a toxic zinc-dithizone complex only at B-pole cells in
contact with the capillary wall. It was shown that in this case, the capillary wall is damaged in the absence of
diabetes, which indicates a direct damaging effect of DZC not only on B-cells but also on the endothelium of
islet capillaries. This is not a direct cause of the development of these forms of diabetes, but may be accompanied
by circulatory disorders in pancreatic islets and a worsening of the course of the disease.
