Abstract:
The article presents literature review on the physicochemical and biological properties of fullerene C60, as
well as the authors' own experimental data on the synthesis of fullerene derivatives of amines and natural
alkaloids. It is shown that the presence of a fullerene fragment in the structure of the compound provides a
significant improvement or the appearance of qualitatively new mechanical, chemical, physical, biological
and other properties associated with the manifestation of nanoscale factors. The issues of the relationship of
the structure, water solubility and biological activity of fullerene С60 derivatives are considered. Many
biologically active effects of various modified derivatives of fullerene C60 are described, which have membrane-
active, antibacterial, antiviral, immunomodulating, HIV inhibitory enzymes and other properties. It was
noted that preparations containing a fullerene fragment are effective against hepatitis C virus, and are also
able to efficiently trap free radicals. Derivatives of fullerenes can also be used as antioxidant, neuroprotective
and other agents. Particular attention is paid to the authors' own results on the synthesis of amino derivatives
of fullerenes.
