Diabetogenic Metabolits of Tryptophan

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dc.contributor.author Meyramov, G.G.
dc.contributor.author Kohnert, K.-D.
dc.contributor.author Shaybek, A.S.
dc.contributor.author DuPont, O.-N.
dc.contributor.author Abdraimova, A.G.
dc.date.accessioned 2017-02-22T06:20:53Z
dc.date.available 2017-02-22T06:20:53Z
dc.date.issued 2016-12-30
dc.identifier.citation Meyramov, G.G. Diabetogenic Metabolits of Tryptophan /G.G. Meyramov, K.-D. Kohnert, A.S. Shaybek a.e.//Қарағанды ун-тінің хабаршысы. Биология.Медицина.География сер=Вестник Караганд.ун-та=Bulletin of the Karaganda university.-2016-№4(84).-P.44-55
dc.identifier.issn 2518-7201
dc.identifier.uri http://rep.ksu.kz/handle/data/1013
dc.description.abstract The analysis of results investigations of mechanisms of diabetogenic activity of metabolits of abnormal tryptophan metabolism as Xanthurenic acid (XA) are presented in review. Among more than 30 diabetogenic chemicals widely known today XA only is formed in animals and elderly human as result of disturbances of tryptophan metabolism. The influence of XA on histostructure of pancreatic islets and on insulin content in B-cells as mechanisms of diabetogenic action and of its prevention are investigated by authors. It was showed that Xanthurenic acid induced diabetes determined by: direct damage of B-cells by Xanthurenic acid accompanied by marked histological changes in islets as destruction and necrosis of B-cells, marked decreasing of insulin content in cytoplasm of cells; by forming of complex XA-insulin that result overstrain of B-cells; by alteration of islet’s capillaries and of blood microcirsulation. ru_RU
dc.language.iso en ru_RU
dc.publisher Вестник Карагандинского университета ru_RU
dc.relation.ispartofseries Биология;
dc.subject B-cells ru_RU
dc.subject Xanthurenic acid ru_RU
dc.subject experimental diabetes ru_RU
dc.subject tryptophan ru_RU
dc.subject pancreas ru_RU
dc.title Diabetogenic Metabolits of Tryptophan ru_RU
dc.type Article ru_RU

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